Hollien Lab
Research Unfolded Protein Response Regulation of mRNA during ER Stress Lysosome Trafficking Hes1 and ER Stress
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Hollien Lab

Publications

 
 
 

Read the Bold articles to learn about the RIDD pathway!

  • Bae D, Jones RE, Piscopo KM, Tyagi M, Shepherd JD, Hollien J. Regulation of Blos1 by IRE1 prevents the accumulation of Huntingtin protein aggregates. Mol Biol Cell. 2022 Nov 1;33(13):ar125. doi: 10.1091/mbc.E22-07-0281.

  • LaBella ML, Hujber EJ, Moore KA, Rawson RL, Merrill SA, Allaire PD, Ailion M, Hollien J, Bastiani MJ, Jorgensen EM. Casein Kinase 1δ Stabilizes Mature Axons by Inhibiting Transcription Termination of Ankyrin. Dev Cell. 2020 Jan 6;52(1):88-103.e18. doi: 10.1016/j.devcel.2019.12.005.

  • Balakrishnan B, Siddiqi A, Mella J, Lupo A, Li E, Hollien J, Johnson J, Lai K. Salubrinal enhances eIF2a phosphorylation and improves fertility in a mouse model of Classic Galactosemia. BBA - Molecular Basis of Disease. 2019.

  • Bae D, Moore K, Mella J, Hayashi S, Hollien J. Degradation of Blos1 mRNA by IRE1 repositions lysosomes and protects cells from stress. Journal of Cell Biology. 2019. 218(4): 1118-1127.

  • Lee JE, Morrison W, Hollien J. Hairy and enhancer of split 1 (HES1) protects cells from endoplasmic reticulum stress-induced apoptosis through repression of GADD34. JBC. 2018. 10.1074/jbc.RA118.002124

  • Nelson J, Moore KA, Chapin A, Hollien J, Metzstein MM. Degradation of Gadd45 mRNA by nonsense-mediated decay is essential for viability. eLife 2016. 10.7554/eLife.12876

  • Moore K, Hollien J. Ire1-mediated decay in mammalian cells relies on mRNA sequence, structure, and translational status. Mol Biol Cell. 2015. 26(16):2873-84.

  • Lee JE, Oney M, Frizzel K, Phadnis N, and Hollien J. Drosophila melanogaster Activating transcription factor 4 Regulates Glycolysis during Endoplasmic Reticulum Stress. G3. 2015. 5(4): 667-75. 

  • Sharma AK, Plant JJ, Rangel AE, Meek KN, Anamisis AJ, Hollien J, Heemstra JM. Fluorescent RNA labeling using self-alkylating ribozymes. ACS Chem Biol. 2014. 9(8):1680-4.

  • Chapin A, Hu H, Rynearson SG, Hollien J, Yandell M, Metzstein MM. In vivo determination of direct targets of the nonsense-mediated decay pathway in Drosophila. G3 (Bethesda). 2014. 4(3):485-96. PMCID: 3962487.

  • Moore KA, Plant JJ, Gaddam D, Craft J, Hollien J. Regulation of sumo mRNA during endoplasmic reticulum stress. PLoS One. 2013. 8(9):e75723. PMCID: 3776770.

  • Gaddam D, Stevens N, Hollien J. Comparison of mRNA localization and regulation during endoplasmic reticulum stress in Drosophila cells. Mol Biol Cell. 2013. 24(1):14-20. PMCID: 3530775.

  • Weil D, Hollien J, Cytoplasmic organelles on the road to mRNA decay, Biochim Biophys Acta- Gene Regulatory Mechanisms 1829 (2013) 725-731.

  • Hollien J, Evolution of the unfolded protein response, Biochim Biophys Acta- Molecular Cell Research 1833 (2013) 2458-2463.

  • Moore KA, Hollien J, The unfolded protein response in secretory cell function, Annu Rev Genet 46 (2012) 165-183.

  • Passos DO, Doma MK, Shoemaker CJ, Muhlrad D, Green R, Weissman JS, Hollien J, Parker R. Analysis of Dom34 and its function in no-go decay. Mol Biol Cell. 2009. 20(13):3025-32. PMCID: 2704154.

  • Hollien J, Lin JH, Li H, Stevens N, Walter P, Weissman JS. Regulated Ire1-dependent decay of messenger RNAs in mammalian cells. J Cell Biol. 2009. 186(3):323-31. PMCID: 2728407.

  • Hollien J, Weissman JS. Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. Science. 2006. 313(5783):104-7.

  • Hollien J, Marqusee S. Comparison of the folding processes of T. thermophilus and E. coli ribonucleases H. J Mol Biol. 2002. 316(2):327-40.

  • Hollien J, Marqusee S. A thermodynamic comparison of mesophilic and thermophilic ribonucleases H. Biochemistry. 1999. 38(12):3831-6.

  • Hollien J, Marqusee S. Structural distribution of stability in a thermophilic enzyme. Proc Natl Acad Sci U S A. 1999. 96(24):13674-8. PMCID: 24123.